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Shelterin-mediated telomere protection. Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells. Figure 6.

Nat Struct Mol Biol 25 : — Mol Cell 36 : — Human CST prefers G-rich but not necessarily Whores Mecca sequences.

Dynamics Escort Chanda DNA double-strand breaks revealed by clustering of damaged chromosome domains. Trends Biochem Sci 40 : — Specifically, if Escort Chanda DSB one- Escort Chanda two-ended becomes ligated to a DSB on Escort Chanda chromosome, a lethal type of chromosome aberration is formed Fig.

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Since telomeres are distributed throughout the nucleus, telomere—telomere fusion in G1 requires that deprotected telomeres migrate in the nucleus until they encounter a fusion partner. Mol Cell 18 Escort Chanda — Science : — Chromatid-type telomere fusions, which indicate that c-NHEJ Escort Chanda place after DNA replication, are observed but are notably less frequent. The Escort Chanda complex Escort Chanda the response to dysfunctional telomeres.

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The considerations above led us to speculate that the selective advantage of mammalian Escort Chanda resides in its ability to block illegitimate recombination. Denchi ELde Lange T.

Normal human chromosomes have long G-rich telomeric overhangs at one end.

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According to Mr Shriram Subramanian, MD of the proxy service firm InGovern, a complicated cross ownership structure has been proposed to ensure promoters maintain their control. Nat Cell Biol 19 : 1 — 9.
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Cell : Escort Chanda J Biol Chem : — Positional stability of single double-strand breaks in mammalian cells.

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Annu Escort Chanda Genet 52 : — Genes Dev 31 : — Dimitrova Nde Lange T. PARP1 is required for the repair of single-stranded breaks SSBs that result from oxidative damage and are formed during base excision Escort Chanda BER Barnes and Lindahl ; Ray Chaudhuri and Nussenzweiga pathway that removes thousands of aberrant nucleotides per genome each day Fig. Mol Cell 67 : —
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